Kim MO, Coiera E, Magrabi F. Problems with health information technology and their effects on care delivery and patient outcomes: a systematic review. Journal of the American Medical Informatics Association. 2016:ocw154.

Abstract Objective: To systematically review studies reporting problems with information technology (IT) in health care and their effects on care delivery and patient outcomes. Materials and methods: We searched bibliographic databases including Scopus, PubMed, and Science Citation Index Expanded from January 2004 to December 2015 for studies reporting problems with IT and their effects. A framework

Y. Wang, E. Coiera, B. Gallego, O. P. Concha, M. S. Ong, G. Tsafnat, D. Roffe, G. Jones and F. Magrabi. (2016). Measuring the effects of computer downtime on hospital pathology processes. J Biomed Inform (Vol. 59, pp. 308-15)

Abstract: Objective: To introduce and evaluate a method that uses electronic medical record (EMR) data to measure the effects of computer system downtime on clinical processes associated with pathology testing and results reporting. Materials and methods: A matched case-control design was used to examine the effects of five downtime events over 11-months, ranging from 5

U. Gurjav, P. Jelfs, G. A. Hill-Cawthorne, B. J. Marais and V. Sintchenko. (2015). Genotype heterogeneity of Mycobacterium tuberculosis within geospatial hotspots suggests foci of imported infection in Sydney, Australia. Infect Genet Evol.

Abstract: In recent years the State of New South Wales (NSW), Australia, has maintained a low tuberculosis incidence rate with little evidence of local transmission. Nearly 90% of notified tuberculosis cases occurred in people born in tuberculosis-endemic countries. We analyzed geographic, epidemiological and genotypic data of all culture-confirmed tuberculosis cases to identify the bacterial and

S. Fu, S. Octavia, M. M. Tanaka, V. Sintchenko and R. Lan. (2015). Defining the Core Genome of Salmonella enterica Serovar Typhimurium for Genomic Surveillance and Epidemiological Typing. J Clin Microbiol (Vol. 53, pp. 2530-8).

Abstract: Salmonella enterica serovar Typhimurium is the most common Salmonella serovar causing foodborne infections in Australia and many other countries. Twenty-one S. Typhimurium strains from Salmonella reference collection A (SARA) were analyzed using Illumina high-throughput genome sequencing. Single nucleotide polymorphisms (SNPs) in 21 SARA strains ranged from 46 to 11,916 SNPs, with an average of

U. Gurjav, B. Burneebaatar, E. Narmandakh, O. Tumenbayar, B. Ochirbat, G. A. Hill-Cawthorne, B. J. Marais and V. Sintchenko. (2015). Spatiotemporal evidence for cross-border spread of MDR-TB along the Trans-Siberian Railway line. Int J Tuberc Lung Dis (Vol. 19, pp. 1376-82).

Abstract: BACKGROUND: Mongolia has the fifth highest incidence of tuberculosis (TB) in the Western Pacific Region, with high rates of multidrug-resistant TB (MDR-TB). OBJECTIVE: To examine the recent spatiotemporal dynamics of MDR-TB in Mongolia. METHODS: All MDR-TB cases diagnosed from 2004 to 2012, identified from the National Tuberculosis Control Programme database, were included in the

V. Sintchenko and E. C. Holmes. (2015). The role of pathogen genomics in assessing disease transmission. BMJ (Vol. 350, pp. h1314).

Abstract: Whole genome sequencing (WGS) of pathogens enables the sources and patterns of transmission to be identified during specific disease outbreaks and promises to transform epidemiological research on communicable diseases. This review discusses new insights into disease spread and transmission that have come from the use of WGS, particularly when combined with genomic scale phylogenetic

X. Zhou, Y. Wang, G. Tsafnat, E. Coiera, F. T. Bourgeois and A. G. Dunn. (2015). Citations alone were enough to predict favorable conclusions in reviews of neuraminidase inhibitors. J Clin Epidemiol (Vol. 68, pp. 87-93).

Abstract: OBJECTIVES: To examine the use of supervised machine learning to identify biases in evidence selection and determine if citation information can predict favorable conclusions in reviews about neuraminidase inhibitors. STUDY DESIGN AND SETTING: Reviews of neuraminidase inhibitors published during January 2005 to May 2013 were identified by searching PubMed. In a blinded evaluation, the

F. Magrabi, S. T. Liaw, D. Arachi, W. B. Runciman, E. Coiera and M. R. Kidd. (2015). Identifying patient safety problems associated with Information Technology in general practice: an analysis of incident reports. BMJ Qual Saf.

Abstract: Objective: To identify the categories of problems with information technology (IT), which affect patient safety in general practice. Design: General practitioners (GPs) reported incidents online or by telephone between May 2012 and November 2013. Incidents were reviewed against an existing classification for problems associated with IT and the clinical process impacted. Participants and setting:

F. Magrabi, M. Baker, I. Sinha, M. S. Ong, S. Harrison, M. R. Kidd, W. B. Runciman and E. Coiera. (2015). Clinical safety of England’s national programme for IT: a retrospective analysis of all reported safety events 2005 to 2011. Int J Med Inform (Vol. 84, pp. 198-206).

Abstract: OBJECTIVE: To analyse patient safety events associated with England’s national programme for IT (NPfIT). METHODS: Retrospective analysis of all safety events managed by a dedicated IT safety team between September 2005 and November 2011 was undertaken. Events were reviewed against an existing classification for problems associated with IT. The proportion of reported events per

A. Y. S. Lau, A. Arguel, S. Dennis, S. T. Liaw and E. Coiera. (2015). “Why Didn’t it Work?” Lessons From a Randomized Controlled Trial of a Web-based Personally Controlled Health Management System for Adults with Asthma. Journal of Medical Internet Research (Vol. 17, pp. e283).

Abstract: Background: Personally controlled health management systems (PCHMS), which may include a personal health record (PHR), health management tools, and information resources, have been advocated as a next-generation technology to improve health behaviors and outcomes. There have been successful trials of PCHMS in various health settings. However, there is mixed evidence for whether consumers will